Cell Culture

E-IP Expan™ Valproic Acid


Epigenetic modifier; enhancing protein expression in mammalian cell cultures.

SKU: 70085 Category:


OverviewProduct ApplicationsData and Publications
Valproic acid (VPA): a viable alternative to sodium butyrate for enhancing protein expression in mammalian cell cultures. VPA can increase γ­aminobutyric acid (GABA) levels via inhibition of enzymes involved in GABA metabolism.

Product Name

E-IP Expan™ Valproic Acid

Catalog #



Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s).

Workflow Stages for

Human Pluripotent Stem Cell Research


Cell Sourcing and Isolation>>Culture and Cryopreservation>>Differentiation>>Characterization



Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., … & Heinzel, T. (2001). Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells. The EMBO journal, 20(24), 6969-6978.

Jeong, S. G., Ohn, T., Kim, S. H., & Cho, G. W. (2013). Valproic acid promotes neuronal differentiation by induction of neuroprogenitors in human bone-marrow mesenchymal stromal cells. Neuroscience letters, 554, 22-27.