Pregnant women currently have the choice to stop medications and putting themselves at risk – or keep taking them and potentially putting their baby at risk.
Using Epiblasts for drug toxicity screening can identify medication that are unhealthy for pregnant women and if needed our tests can show safer alternatives.
Little is know about your medication
Research done by the Centers for Disease Control and Prevention found that of the 54 most common medications pregnant women use in the first trimester, 63% had very limited risk data and only 4% had excellent data.
We test your medication
To see if it stops epiblast development, weakens the amniotic sac, or stops primitive streak development. These deformities can cause stillbirths or miscarriages. We screen for these problems with our Epiblast model.
During pregnancy 97% of the woman took at least one medication with 95% taking a medication in the first trimester (Haas, 2018). Even though strict regulations put in place by the FDA, unfortunately a study in 2001 found that there was not enough information about the risk or safety of 91% medications approved by FDA, between 1980 and 2000 when taken during pregnancy (Lo & Friedman, 2002). Another study between 2000 and 2010 showed the same gap in knowledge (Adam, Polifka, & Friedman, 2011). This is because pregnant women are usually excluded from medical trials.
Fear of causing fetal harm and death through medication use in pregnancy, makes it difficult for women and health care providers to decide whether to use medications during pregnancy or not (Ward, 2001). Because of these ethical considerations, researchers like Gerald Briggs believe that this problem will not be resolved in the near future (Briggs et al., 2015).
Medication safety information in pregnancy is at the moment obtained through case reports, epidemiological studies and animal studies; all of which have limitations, that make determining risks of a drug use during pregnancy difficult (Ward, 2001). We at Cellulim aim to determine risks of a drug during pregnancy by producing and selling synthetic human epiblasts generated solely from embryonic stem cells or induced pluripotent stem cells. This approach while generating large numbers of synthetic human epiblasts, used as test solutions to problems of pregnancy failure and the embryonic origin of diseases.
Get started in a few simple steps.
Order a kit with
easy-to-follow instructions (we are committed to maintaining the privacy of all personal information entrusted to us).
Medication Kit Activation
Activate your kit and return your medication sample in a prepaid package to our state-of-the-art lab.
In roughly 6-8 weeks your results will be ready online.
Note: lab processing times may be increased due to high demand.
Haas, D. M., Marsh, D. J., Dang, D. T., Parker, C. B., Wing, D. A., Simhan, H. N., … & Parry, S. (2018). Prescription and Other Medication Use in Pregnancy. Obstetrics & Gynecology, 131(5), 789-798.
Food and Drug Administration. (2014) Content and format of labeling for human prescription drug and biological products: requirements for pregnancy and lactation labeling. Fed Regist, 79(233), 72064–72103.
Lo, W. Y., & Friedman, J. M. (2002). Teratogenicity of recently introduced medications in human pregnancy. Obstetrics & Gynecology, 100(3), 465-473.
Sachdeva, P., Patel, B. G., & Patel, B. K. (2009). Drug use in pregnancy; a point to ponder!. Indian journal of pharmaceutical sciences, 71(1), 1.
Smithells, R. W., & Newman, C. G. (1992). Recognition of thalidomide defects. Journal of medical genetics, 29(10), 716.