low back pain is an universal human experience. Almost everyone will experience it at some point. The lower back which starts just above the pelvis (hip) and is called the lumbar region. Pain in this region can be intense and has major socioeconomic impact. Fortunately often the pain gets better on its own. When it doesn’t you should visit a doctor.
For example disc degeneration is a musculoskeletal condition affecting 80% of the whole global population. The well known low back pain has major social and economic impact. In the past 30 years promising therapies have been investigated for the treatment of degenerative Disc Disease and these have identified stem cell therapies with Mesenchymal stem cells as one of the major promising treatments.
Early clinical trails (phase 1 en 2) and animal model studies with Mesenchymal stem cells yielded impressive results in disc degeneration repair. More effective are combinatorial therapeutic approaches. Like biomaterial and cell-based therapies these combination will be used in disc degeneration repair in the near future.
Administration of autologous Mesenchymal Stem Cells in two small groups of patients with disc degeneration resulted in clinical improvement in 9 of 10 patients compared to conservative treatment which failed. A majority of the MSC treated patients achieved minimal levels of residual back pain. A Phase III clinical trial is currently being conducted on the use of Mesenchymal stem cells for the treatment of disc degeneration in 25 centers in United states and the findings of these studies will be very important for the treatment of disc degeneration.